NVC-422 Inactivates Staphylococcus aureus Toxins
نویسندگان
چکیده
منابع مشابه
NVC-422 inactivates Staphylococcus aureus toxins.
Bacterial pathogens have specific virulence factors (e.g., toxins) that contribute significantly to the virulence and infectivity of microorganisms within the human hosts. Virulence factors are molecules expressed by pathogens that enable colonization, immunoevasion, and immunosuppression, obtaining nutrients from the host or gaining entry into host cells. They can cause pathogenesis by inhibit...
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BACKGROUND Bacterial biofilms are a major obstacle in management of recalcitrant chronic rhinosinusitis. NVC-422 is a potent, fast-acting, broad-spectrum, nonantibiotic, antimicrobial with a new mechanism of action effective against biofilm bacteria in in vitro conditions. The aim of this study was to investigate the safety and efficacy of NVC-422 as local antibiofilm treatment in a sheep model...
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Staphylococcus aureus is a dangerous pathogen that causes a variety of severe diseases. The virulence of S. aureus is defined by a large repertoire of virulence factors, among which secreted toxins play a preeminent role. Many S. aureus toxins damage biological membranes, leading to cell death. In particular, S. aureus produces potent hemolysins and leukotoxins. Among the latter, some were rece...
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INTRODUCTION ..... .. 320 STAPHYLOCOCCAL SCALDED SKIN SYNDROME 322 Experimental Model 324 Association of the Staphylococcal Scalded Skin Syndrome with Exfoliative Toxin ................. ... .324 EXFOLIATIVE TOXIN 325 Production 325 Isolation and Purification ... 326 Properties .. 326 Genetic Regulation ......................... ..... 331 ALPHA-TOXIN ......................... ...... 337 Overvie...
متن کاملExfoliative Toxins of Staphylococcus aureus
Staphylococcus aureus is an important pathogen of humans and livestock. It causes a diverse array of diseases, ranging from relatively harmless localized skin infections to life-threatening systemic conditions. Among multiple virulence factors, staphylococci secrete several exotoxins directly associated with particular disease symptoms. These include toxic shock syndrome toxin 1 (TSST-1), enter...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2012
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01945-12